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Incidence of bleeding after minor oral surgery in patients on dual antiplatelet therapy: A systematic review and meta-analysis

International Journal of Oral & Maxillofacial Surgery Jun 28, 2019

Ockerman A, et al. - In this systematic review and meta-analysis, researchers assessed bleeding with minor oral surgery in patients on dual antiplatelet therapy (DAPT), single antiplatelet therapy (SAPT), or no antiplatelet therapy (no APT). They included 16 studies for this analysis. Investigators found that the perioperative bleeding risk was significantly higher for DAPT than for SAPT, but not higher vs no APT. It was noted that the postoperative bleeding risk was significantly elevated for DAPT vs SAPT (risk ratio [RR] 2.61) and no APT (RR 3.63), but only by 1% (risk difference [RD] 0.01) and 1% (RD 0.01), respectively. Clinically, this may be considered quite similar. This can be considered quite similar clinically. In addition, all reported bleeding could be controlled by local haemostatic measures, and no lethal events occurred. DAPT interruption is therefore not recommended prior to minor oral surgery.
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