Dibek Misirlioglu E, et al. - The incidence of rash and antibiotic allergy was investigated in antibiotic-treated patients with a positive Epstein-Barr Virus (EBV) IgM who developed a rash between 2013 and 2016. Antibiotic treatment was received during disease by 54.3% patients. Rash developed in 18.6% patients, and 16.6% of them were treated with antibiotics (most frequently aminopenicillins: 72.5%), and 20.8% were not treated with antibiotics. Compared to previous reports, findings showed a much lower incidence of drug hyper­sensitivity. Of reactions that occurred during infectious mononucleosis, some were transient, and some were true drug hypersensitivity reactions. Assessment of these with allergy tests was recommended prior to use of these drugs after EBV infection.