Chatterjee NA, Kume K, Drucker C, et al. - Findings revealed the occurrence of 350 air travel‐associated out of hospital cardiac arrest (OHCA) in the United States and 2000 OHCA globally each year, approximately a quarter of which occur on‐plane. When early arrest interventions such as rapid arrest recognition, automated external defibrillator (AED) application, and cardiopulmonary resuscitation (CPR) are deployed, these events are survivable.

• This study cohort comprised air travelers (aged ≥18 years) with OHCA treated by emergency medical services (EMS).

• Study was run for 16 years, and revealed 143 OHCA happening before EMS arrival, 34 (24%) on‐plane and 109 (76%) off‐plane, and the most common mechanism of arrest was cardiac etiology (81%).

• Bystander‐witnessed arrests and a shockable rhythm were more common in off‐plane OHCA vs on‐plane (witnessed: 89% vs 74% and shockable: 72% vs 50%).

• Irrespective of arrest location, pre‐EMS therapies including CPR and AED application were common.

• Greater rates of return of spontaneous circulation and 3‐fold higher rate of survival to hospital discharge were noted in off‐plane OHCA vs on‐plane OHCA.

• All on‐plane OHCA survivors received AED application with defibrillation prior to EMS arrival.