Gao K, Fu J, Guan X, et al. - Given that one of the leading causes of infant morbidity and mortality in China is neonatal sepsis (NS), researchers here investigated pathogen incidence and distribution. In this retrospective study (January 2012 to December 2016), they analyzed pathogen incidence and antimicrobial resistance in culture-proven cases aged less than 28 days with diagnosed NS in the Guangzhou Women and Children’s Medical Center, South China. They identified 620 isolates from 597 NS cases. They isolated Gram-negative bacteria (n = 371, 59.8%) more frequently than Gram-positive bacteria (n = 218, 35.2%) and fungi (n = 30, 4.8%). The four most predominant pathogens were Klebsiella pneumoniae (21.9%), Escherichia coli (21.9%), group B Streptococcus (GBS, 13.2%), and Staphylococcus aureus (6.8%). K. pneumoniae was primarily associated with late-onset sepsis in preterm, whereas GBS was the dominant pathogen in early-onset sepsis. In both episodes, E. coli was common with the highest mortality.