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Incidence and risk factors of keratinocyte carcinoma after first solid organ transplant in Ontario, Canada

JAMA May 27, 2019

Park CK, et al. - Using linked administrative databases and a health insurance claims–based algorithm, researchers conducted this population-based inception cohort study in Ontario, Canada to estimate the incidence and identify risk factors for posttransplant keratinocyte carcinoma (KC), also known as nonmelanoma skin cancer. The study included a total of 10,198 transplant recipients. Older age at transplant, white race, pretransplant invasive skin cancer, and posttransplant precancerous skin lesions were the strongest risk factors for KC. In the high-risk patient subsets identified by key risk factors, more frequent skin cancer screening, education and early use of chemopreventive interventions may be warranted.
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