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Incidence and risk factors of keratinocyte carcinoma after first solid organ transplant in Ontario, Canada

JAMA Sep 18, 2019

Park CK, Fung K, Austin PC, et al. - Through a population-based cohort study of 10,198 transplant recipients in Ontario, Canada, researchers evaluated the incidence and recognized risk factors for posttransplant keratinocyte carcinoma (KC, also called nonmelanoma skin cancer, is the most prevalent malignancy following a solid organ transplant). The most powerful independent risk factors for KC comprised elderly age at transplant, white vs black race, pretransplant invasive skin cancer, and posttransplant precancerous skin lesions. The incidence of KC seemed to be substantially raised following transplant, especially in patients who were elderly at transplant, were white, and had a history of cancerous or precancerous skin tumors and intensified skin cancer screening, education, and early use of chemopreventive interventions may be guaranteed for these high-risk patient subsets.
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