Charlton JR, et al. - In the Assessment of Worldwide AKI Epidemiology in Neonates (AWAKEN), an international retrospective observational cohort study, researchers investigated risk factors and outcomes of neonatal AKI in the first postnatal week. Participants included neonates admitted to a neonatal intensive care unit who received at least 48 hours of intravenous fluids. They found a common occurrence of AKI in the first postnatal week, which was found to be related to death and longer duration of hospitalization. The factors that showed relation to a higher risk of AKI were: outborn delivery; resuscitation with epinephrine; admission diagnosis of hyperbilirubinemia, inborn errors of metabolism, or surgical need; frequent kidney function surveillance; and admission to a children’s hospital. Multiple gestations, cesarean section, and exposures to antimicrobials, methylxanthines, diuretics, and vasopressors were related to lower risk. Variations were seen in the risk factors by gestational age strata.