Incidence and risk factors of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: A systematic review and meta-analysis of cohort studies
Journal of Thoracic Disease Sep 01, 2018
Zhang M, et al. - Researchers evaluated the incidence and risk factors of chronic thromboembolic pulmonary hypertension (CTEPH) after acute pulmonary embolism (PE), via a systematic review and meta-analysis of only cohort studies that used right heart catheterization for CTEPH diagnosis. The inclusion criteria was met by 15 studies. According to findings, CTEPH is not a rare complication of acute PE. With a median follow-up from 6 to 94.3 months, the estimated overall incidence of CTEPH after acute PE was 3.13%. Studies from China vs from Europe reported a slightly higher incidence. In patients with a previous PE, the considered risk factors of CTEPH included previous/recurrent PE or previous venous thromboembolism, idiopathic PE and right heart dysfunction. Findings call for close follow-up and implementation of a comprehensive screening program, especially in patients with independent risk factors.
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