Nowilaty SR, Alsalamah AK, Magliyah MS, et al. - In this retrospective case series, researchers analyzed the incidence and natural history of macular retinochoroidal neovascularization (RCN) in Enhanced S-Cone Syndrome (ESCS), an autosomal recessive retinal dystrophy. Participants in the study were 14 out of 93 patients with ESCS, who had signs of active or inactive RCN in at least one eye. RCN, a treatable condition, can occur as early as 2 years of age and can be much more common in ESCS than reported previously. It can be the primary cause of unifocal submacular fibrosis that is usually seen in this condition. Further research is required to determine the pathogenesis of RCN in ESCS and its optimal management.