Ho AS, Luu M, Barrios L, et al. - Researchers conducted a cohort study to investigate the incidence, clinicopathologic characteristics, and outcomes for aggressive variants of papillary thyroid carcinoma (PTC). Researchers applied data from 2000 to 2016 from hospital-based and population-based US cancer registries to examine aggressive PTC variants, including diffuse sclerosing (DSV), tall-cell (TCV), insular and poorly differentiated (PDTC) subtypes. Between January 2019 and October 2019, these variants were matched against WDPTC and anaplastic cases. They performed a Data analysis. They further observed an upsurge in aggressive PTC incidence at a rate beyond that seen in WDPTC or anaplastic thyroid carcinoma. Furthermore, long-term survival results for aggressive PTC subgroups exhibit heterogeneous clinical behavior and a wide range of mortality risk, implying that treatment should be tailored to specific histologic subtypes. Given the rising prevalence and disparate outcomes, future research to distinguish optimal therapeutic strategies is required in these diverse, understudied populations.