Özger HS, Fakıoğlu DM, Erbay K, et al. - Researchers conducted a prospective observational study evaluating gram-positive anti-bacterial utilizations in ICUs with various evaluation criteria, the frequency of inappropriate usage and the intervention targets required to ensure optimum use. From the medical and surgical ICUs of Gazi University Faculty of Medicine Hospital, Turkey, they included 169 patients who were prescribed gram-positive spectrum antibiotics (vancomycin, teicoplanin, linezolid, and daptomycin) from October 1, 2018 to October 1, 2019; patients were older than 18 years and had undergone 200 treatments. Observations revealed inappropriate gram-positive antibiotic use in ICUs as high as 83% in terms of non-compliance with the selected quality parameters. Per multivariate analysis, increased creatinine levels were identified to increase the risk of such use. These findings emphasize the necessity for adopting local guidelines in collaboration with different disciplines for the determination and follow-up of de-escalation of such use and optimal treatment doses.