Di Rosa R, et al. - Researchers evaluated 520 consecutive clinical records of infertile women undergoing in vitro fertilization (IVF) for the prevalence of antiphospholipid antibodies (aPLs). Among these, 100 (19.23%) women had positive auto-antibodies: 35/520 (6.73%) fulfilled classification criteria for a systemic disease. In 43 women (8.27%), positive aPLs were observed: 17/520 (3.27%) fulfilled diagnostic criteria for PAPS/APS, whereas patients with positive aPLs, who fulfilled diagnostic criteria for a systemic autoimmune disease other than APS were 18/520 (3.46%). As per observations, women with infertility seem to represent a subpopulation of patients with underhanded systemic autoimmune syndromes in which the main symptoms represented are obstetrical complications. Hence, all patients undergoing IVF should be investigated for aPLs to identify the women at a higher risk of miscarriage or pregnancy morbidity.