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In utero antihypertensive medication exposure and neonatal outcomes

Hypertension Jan 10, 2020

Fitton CA, Fleming M, Steiner MFC, et al. - Given a significant risk to mother and fetus in correlation to hypertensive disorders during pregnancy, frequently necessitating antihypertensive treatment, researchers conducted this retrospective cohort study utilizing linked routinely collected healthcare records for 268,711 children born 2010–2014 in Scotland, to appraise consequences following in utero exposure to antihypertensive medication. A cohort of 265,488 eligible children born over the study period was recognized; among these, exposure to in utero antihypertensive medication was noted in 2,350, exposure to treated late-onset hypertension was reported in 4,391, and exposure to untreated hypertension during pregnancy was noted in 7,971. Outcomes indicate that for low birth weight and preterm birth, hypertension is a key risk factor. Although antihypertensive medication exposure during pregnancy may correlate to preterm birth, these associations may indicate progressing hypertension severity requiring treatment.
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