Salazar-Austin N, Cohn S, Barnes GL, et al. - Via performing a pragmatic, cluster-randomized trial, researchers aimed at ascertaining if contact evaluation using symptom screening improved the proportion of identified child contacts who initiated tuberculosis preventive therapy (TPT), compared with tuberculin skin testing (TST)-based screening, in Matlosana, South Africa. Sixteen clinics were randomized to either symptom-based or TST-based contact evaluations. In the symptom and TST arms, contact tracing led to identification of 550 and 467 child contacts, respectively (0.39 vs 0.32 per case, respectively). observations revealed no improvement in the proportion of identified child contacts evaluated or initiated on TPT in correlation with symptom-based screening vs TST-based screening.