Chamorro–de–Vega E, et al. – Here the authors illustrated the outcomes of the implementation of a comprehensive pharmaceutical care programme (CPCP) for hepatitis C virus (HCV)–infected patients treated with direct–acting antivirals (DAA). Results approved that the implementation of a CPCP was an effective approach that improves patient safety and education. Moreover, the active involvement of the pharmacist in improving adherence to local guidelines promoted the selection of the most cost–effective treatment in the majority of cases.