De Paepe KN, et al. - In this retrospective study, the researchers assessed first-order apparent diffusion coefficient (ADC) texture parameters compared to mean ADC for lymph node characterization in non-Hodgkin lymphoma (NHL) using whole-body diffusion-weighted (WB-DWI). Participants in the study were 28 patients with NHL. They compared the diagnostic performance of mean ADC (ADC_mean) with first-order ADC texture parameters standard deviation (ADC_stdev), kurtosis (ADC_kurt), and skewness (ADC_skew). Compared to ADC_mean, first-order ADC texture analysis with WB-DWI improved lymph node characterization. The most accurate and vigorous discriminatory parameter over all lymph node volumes and nodal body regions was ADC_skew.