Ishibashi F, et al. – In this study, researchers investigated the effect of normalizing HbA_1c by extensive HbA_1c control (EHC) on neuropathy outcome measures (NOMs), nephropathy, and retinopathy in patients with type 2 diabetes. Researchers performed detailed clinical and neurological examinations in two cohorts of 38 patients with uncontrolled type 2 diabetes at baseline and after glycemic control (GC) with or without EHC through diet restrictions and hypoglycemic agents over 4 years, with 48 control participants with normal glucose tolerance (NGT) and 34 participants with impaired glucose tolerance (IGT) at baseline only. Compared with the standard GC, the normalization of HbA_1c in type 2 diabetes of short duration improves microvascular complications, including neuropathy and nephropathy, but not retinopathy more effectively.