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Importance of supplemental patch testing beyond a screening series for patients with dermatitis

JAMA Nov 09, 2021

Warshaw EM, Buonomo M, DeKoven JG, et al. - In allergic contact dermatitis, proper identification of allergens and successful management can be ensured via comprehensive patch testing with more than 70 allergens, including supplemental series and personal and work materials.

  • This is a 17-year cross-sectional analysis of North American Contact Dermatitis Group (NACDG) data, including 43,417 patients with dermatitis who had patch testing to the NACDG screening series (65-70 allergens).

  • Among these, a currently relevant reaction to 1 or more supplemental allergens or substances was evident in 21.9% of patients.

  • Of these patients, 26% showed no currently relevant reactions to 65 to 70 screening allergens.

  • Significantly less probability of being male (odds ratio OR, 0.90) and/or having atopic dermatitis (OR, 0.89) was observed in patients with supplement-positive findings vs those who had supplement-negative results.

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