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Importance of hypersensitivity in adverse reactions to drugs in the elderly

Clinical and Molecular Allergy Apr 08, 2018

Ventura MT, et al. - Researchers intended to offer data on possible inappropriate prescriptions in the elderly in relation to allergic reactions. They also identified a list of drugs which are likely inducers of allergic reactions. Using Beers criteria, they retrospectively assessed adverse drug reactions (ADRs) in patients referring to Immunoallergy Unit of Hospital Policlinico in Bari. Out of all ADRs documented, hypersensitivity drug reaction (HDR) represented 5–10%. A prevalence of about 30% was noted in this study population. Some of the drugs that were found to be responsible for HDRs included antibiotics, NSAIDs, acetylsalicilic acid, antihypertensive drugs, antiacids, psicotropic agents and anesthetics. Findings called for strategies to minimize the incidence of drug allergy in the elderly, as well to attenuate the phenomenon of inappropriate prescriptions.
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