Sharma A, et al. - In this patient-level combined-analysis, researchers assessed the efficacy of a strategy of implantable cardioverter-defibrillator (ICD) plus medical therapy compared to medical therapy alone in patients with heart failure (HF) and diabetes. They used a combined dataset with four primary prevention ICD trials of patients with HF or severely reduced ejection fractions: Multicenter Automatic Defibrillator Implantation Trial I (MADIT I), MADIT II, Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE), and Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). They found no significant association of primary prevention ICD in combination with medical therapy, relative to medical therapy alone, with a reduced risk of all-cause death.