Goldberg I, et al. - A retrospective analysis of a large cohort of subjects attending a medical screening center in Israel was conducted to assess the yearly decline of glomerular filtration rate (GFR) among impaired fasting glucose (IFG) patients. Eight thousand, one hundred seventy-six subjects were included. Compared with healthy subjects, impaired fasting glucose was correlated with a decreased rate of GFR reduction and this effect was shown among men but not among women. A mechanism of glomerular hyperfiltration could be involved.