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Impact of urinary sodium on cardiovascular disease and risk factors: A 2 sample Mendelian randomization study

Clinical Nutrition Sep 25, 2020

Yeung SLA, et al. - Given that sodium raises the risk of coronary artery disease and hypertension, however, there is less clarity if sodium also influences other cardiovascular disease (CVD) and its risk factors, so, researchers applied Mendelian randomization to investigate the causal role of urinary sodium in these CVDs and risk factors. Utilizing the most up to date genome wide association studies (GWAS), experts found strong, independent single nucleotide polymorphisms of urinary sodium and these were applied to GWAS of stroke and its subtypes, atrial fibrillation and heart failure. According to the findings, increased risk of stroke, heart failure and type 2 diabetes may be seen in relation to higher sodium. Public health policies to minimize population sodium consumption were further supported by these data in order to attenuate the associated disease burden.

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