Ye LL, et al. - Researchers sought the potential variables influencing patient survival following primary surgery for hypopharyngeal squamous cell carcinoma. They analyzed the clinicopathological features of 93 patients with primary hypopharyngeal squamous cell carcinomas who underwent radical surgery at Fudan University Shanghai Cancer Center between August 2007 and December 2016. Outcomes revealed that patients with depth of invasion ≥ 4.3 mm, primary tumor volume ≥ 0.36 mL, or lymph node density ≥ 0.07 had inferior overall survival and disease-specific survival. Hence these factors could help the selection of suitable candidates for more aggressive adjuvant therapy.