Kim YH, et al. - This study was undertaken to determine the additional long-term benefit of treating patients with significant coronary artery spasm (CAS) with trimetazidine combined with well-known antispasmodic agents such as calcium channel blockers and nitrate. Findings demonstrated that when assessed by acetylcholine provocation test, the additional long-term (5-year) treatment with trimetazidine in combination with diltiazem and nitrate vs combination therapy with diltiazem and nitrate only (without trimetazidine) was not associated with improved clinical outcomes in the studied population.