Koge J, Matsumoto S, Nakahara I, et al. - Researchers examined how thrombus migration influences the clinical outcomes in patients with internal carotid artery (ICA) occlusions and patent middle cerebral artery (MCA). Thirty-eight patients with acute ischemic stroke compromising ICA occlusions and patent MCA who underwent consecutive hospitalization between January 2006 and March 2016 were retrospectively analyzed. Assessment of thrombus migration was done (1) via investigating the discrepancies in arterial occlusion sites between initial imaging and follow-up imaging and (2) via probing how occlusion sites changed during endovascular therapy. Ten patients (26%) exhibited thrombus migration (spontaneous: 3; during endovascular therapy: 7). Outcomes revealed a correlation of thrombus migration with poor prognosis in these cases. Findings thereby emphasize performing careful monitoring under these conditions even if the initial clinical presentation is mild.