Backus LI, et al. - In this study involving 15,059 hepatitis C virus–infected patients with advanced liver disease (defined by a FIB-4 > 3.25), researchers assessed the impact of direct-acting antiviral-induced sustained virologic response (SVR) on all-cause mortality and hepatocellular carcinoma (HCC) incidence. In total, 1,067 patients failed to achieve SVR, while 13,992 patients did. Investigators observed that those who achieved SVR after direct-acting antiviral treatment had significantly lower all-cause mortality and lower HCC incident rates than those who did not achieve SVR. The researchers concluded that there may be an independent association of history of decompensated liver disease and decreased albumin with an increased risk of death.