Kim YH, Her AY, Jeong MH, et al. - Since there exists limited data on the influence of stent generation on long-term results in ST-segment elevation myocardial infarction (STEMI) patients having a multivessel disease (MVD) who received the primary percutaneous coronary intervention (PCI) with culprit-only PCI (C-PCI) or multivessel PCI (M-PCI), researchers performed this study with 7,266 patients to assess the occurrence of major adverse cardiac events (MACE) (primary endpoint) as well as the cumulative incidence of stent thrombosis (ST) at 2 years (secondary endpoint) in two groups of patients, a C-PCI (n = 4,901) or M-PCI group (n = 2,365). In STEMI patients with MVD, the estimated cumulative incidence of MACE was found to be the lowest for second-generation-drug-eluting stents (DES), the highest for bare-metal stents, and intermediate for first-generation (1G)-DES following C-PCI or M-PCI. However, irrespective of stent generation, a similar cumulative incidence of ST was observed in the two distinct reperfusion strategy groups.