Mashaly A, et al. - In this study including 2,416 patients without significant coronary artery lesion (< 50% stenosis) by coronary angiography and having undergone acetylcholine (ACh) provocation test, researchers determined the influence of serum lipoprotein(a) (Lp[a]) levels on the incidence and severity of endothelium-dependent coronary vasomotor response. Up to 5 years, they compared the composite of total death, myocardial infarction, and de novo percutaneous coronary intervention between patients categorized according to their serum Lp(a) level into four quartile groups (less than 6.70, 6.70–13.30, 13.30–26.27, and more than 26.27 mg/dl). They found no link between the elevated Lp(a) level and the vasospastic response to the intracoronary ACh provocation test; however, poor clinical outcomes up to 5 years were related to higher Lp(a) levels.