Mwenda JM, Hallowell BD, Parashar U, et al. - Utilizing data from the African Rotavirus Surveillance Network (ARSN), researchers reported the proportion of rotavirus acute gastroenteritis (AGE) cases by year relative to vaccine introduction, and the relative reduction in the proportion of rotavirus AGE cases reported following vaccine introduction. For descriptive analysis, they involved all sites reporting to ARSN for any length of time between 2008 and 2018. From 2008 to 2018, 97,366 prospectively recruited hospitalized children < 5 years of age met the case definition for AGE, and 34.1% tested positive for rotavirus. The introduction of the rotavirus vaccine resulted in significant and consistent decreases in the proportion of hospitalized AGE cases that tested positive for rotavirus. To maximize the public health benefit of these vaccines, efforts should be made to introduce and improve coverage of rotavirus vaccines in the region's remaining countries.