Gorostidi M, Ruiz R, Villalain C, et al. - A definitive histological evaluation of hysterectomy and bilateral adnexectomy samples results in upstaging in nearly 10% of patients with an intra-operative diagnosis of low-risk endometrial cancer (EC). Researchers sought to determine the results linked with the performance of pelvic and para-aortic lymphadenectomy for restaging after upstaging/upgrading these patients. In addition, they compared those who underwent sentinel lymph node biopsy (SNB) in the first procedure with those who did not. In this retrospective cohort study, 27 patients diagnosed with low-risk EC were included, who underwent surgical laparoscopic restaging due to upstaging based on the final histological result at Hospital Universitario Donostia from April 2013 to September 2018. Patients who underwent hysterectomy and double adnexectomy without any additional procedures (SNB-; n = 17) and patients who also underwent pelvic and aortic SNB (SNB+; n = 10) were compared with respect to surgical and oncological results. Outcomes revealed increased risk of complications in second restaging surgery following upstaging of endometrial cancer. Restaging surgery is identified to be a more complex procedure, particularly in cases with a prior sentinel node biopsy. Based on findings, they advise against performing second restaging surgery in patients who have undergone sentinel node biopsy.