Kakuta K, et al. - This study was performed on patients with type 2 diabetes mellitus (T2DM) in order to assess the role of renal function in the contributory effects of blood glucose fluctuations and blood levels of inflammatory cytokine concentrations on the tissue characteristics of coronary plaques in these subjects. In this patient population, patients with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m² demonstrated association of tissue characteristics of coronary plaques with mean amplitude of glycemic excursions (MAGE), while patients with eGFR < 60 mL/min/1.73 m² showed a link between tissue characteristics of coronary plaques and serum tumor necrosis factor (TNF)-α.