Hart SA, Nandi D, Backes CH, et al. - This study was attempted to assess the effect of prenatal screening on congenital heart defects in neonates with Down syndrome in the US. Between 2007 and 2018, researchers obtained encounters for neonates with Down syndrome (DS) from the Pediatric Health Information System database. They classified congenital heart defects (CHD) as complex CHD, atrioventricular septal defects, ventricular septal defects, and tetralogy of Fallot. A total of 9,122 patients were included in the study. The results illustrate that in patients with DS, the proportion of CHD seems to be stable despite the widespread adoption of non-invasive prenatal screening in the US. They found variations between states with low vs. high access to pregnancy termination. Population-based trials are required to fully analyze the current epidemiology of CHD in DS.