Ardeljan AD, Polisetty TS, Palmer JR, et al. - The present study was conducted to examine postoperative zolpidem use in the total knee arthroplasty (TKA) population regarding medical and implant complications, falls, and readmission. According to zolpidem use, the study group was queried. In this study, outcomes yielded 99,178 study participants and 495,795 controls. Ninety-day medical and implant complications, fall risk, and readmission were the primary outcomes. Categorical variables were compared by using the Chi-squared test. Multivariate logistic regression was applied to estimate odds (OR) for complications, fall risk, and readmission. It was shown that zolpidem use following primary TKA is correlated with the risk of morbidity and falls. The data are consistent with the literature regarding zolpidem. These data may influence discussion between orthopedic surgeons and individuals in the decision-making process prior to undergoing TKA.