Tsujimoto H, Horiguchi H, Takahata R, et al. - Researchers intended to determine if there is an association between high mobility group box chromosomal protein-1 (HMGB-1) and clinicopathological factors and long-term prognosis after esophagectomy for esophageal cancer. They used ELISA and HMGB-1 protein to measure perioperative serum HMGB-1 levels through induction of immunohistochemistry in resected samples. Compared with preoperative levels, postoperative serum HMGB-1 levels were significantly higher. In patients with more intraoperative bleeding, longer intensive care unit stays, and postoperative pneumonia, preoperative serum HMGB-1 levels were significantly higher. Elevated postoperative serum HMGB-1, which was associated with poor long-term outcomes as well as short-term outcomes like postoperative complications, could serve as a potential marker for esophageal cancer prognosis.