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Impact of paranasal sinus surgery in granulomatosis with polyangiitis: A longitudinal computed tomography study

The Laryngoscope Apr 08, 2020

Holme SS, et al. - Researchers conducted this longitudinal observational study to explore time‐dependent association between sinus surgeries and computed tomography (CT) imaging features in the chronic rhinosinusitis (CRS) of granulomatosis with polyangiitis (GPA). They evaluated CRS characteristics including bone thickening by global osteitis scoring scale, bone erosions, and mucosal thickening by Lund‐Mackay scores in serial paranasal sinus CT scans (742 CT scans in total) from a cohort of 127 well‐characterized GPA patients. The authors discovered that 23/127 cohort patients had one or more paranasal sinus surgical procedures, and 96% of these (22/23) had osteitis by CT after surgery. In this cohort, paranasal sinus surgery was related to prevalence, severity, and progression rate of sinus osteitis, suggesting that sinus surgery does not decrease the bone damage development in the CRS of GPA.

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