Okala SG, Darboe MK, Sosseh F, et al. - Via the Early Nutrition and Immune Development (ENID) trial , a randomized, partially blinded trial done between April 2010 and February 2015 in the rural West Kiang region of The Gambia, researchers investigated the impacts of maternal nutritional supplementation during pregnancy on infants’ antibody responses to the diphtheria-tetanus-pertussis (DTP) vaccine involved in the Expanded Programme on Immunisation (EPI). A total of 875 pregnant women who were randomized to receive either iron-folic acid alone or combined with multiple micronutrients (MMN), protein-energy (PE), or PE + MMN daily from recruitment until delivery were enrolled. Supplementation with MMN combined with PE was the most effective intervention examined, increasing mean antibody titers against diphtheria and tetanus at 12 weeks, and tetanus and pertussis titres at 24 weeks. Thus, according to the outcomes from the rural Gambia, in early infancy, maternal supplementation with MMN combined with PE during pregnancy improved antibody responses to the DTP vaccine. Further, the provision of nutritional supplements to pregnant women in food insecure settings may enhance infant immune development and responses to EPI vaccines.