Dalla K, et al. - Researchers investigated how right ventricular (RV) systolic function, afterload and pulmonary haemodynamics were influenced by norepinephrine-induced alterations in mean arterial pressure (MAP) in septic shock patients included in this observational study. They sought to determine whether RV systolic function improves at higher doses of norepinephrine/MAP levels. They titrated norepinephrine infusion to target MAP of 60, 75 and 90 mmHg in a random sequential order. Findings revealed improved RV systolic function, but unaltered RV afterload, resulting from higher doses of norepinephrine to a target MAP of 90 mm Hg.