Tiwari R, Narayanan GS, Reddy VP, et al. - Researchers conducted this comparative study including 161 patients with node-positive locally advanced cervical cancer (LACC) treated with definitive chemoradiation and MRI-based brachytherapy with the aim to prospectively evaluate the influence of dose-escalated irradiation of nodal metastases on clinical outcomes compared with no boost in these patients. In high-risk cervical cancer, excellent loco-regional control was achieved in correlation with adding external radiation nodal boost to standard treatment. Observations suggest a strong predictive value of pelvic nodal volume for relapse and survival. However, there were high systemic failures that continue to pose a challenge in improving survival outcomes.