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Impact of margin status on survival after surgery for sinonasal squamous cell carcinoma

International Forum of Allergy & Rhinology Nov 08, 2019

Jafari A, et al. - Considering the literature's heterogeneity of the effect of positive surgical margins (PSM) on overall survival (OS), researchers tested the belief that extent of tumor extirpation (microscopic PSM vs macroscopic PSM) can play a role in OS. Seven thousand eight hundred eight patients with sinonasal squamous cell carcinoma (SNSCC; most common malignancy of the paranasal sinuses) were identified in the National Cancer Database. Of these, 4,543 individuals had surgery, 3,265 individuals had nonsurgical treatment. The authors discovered that 1,033 of the surgery patients had PSM, and about half of these had macro-PSM. Data reported that the degree of extirpation of the tumor correlates with OS. Compared with nonsurgical treatment, macro-PSM did not confer an advantage on OS, and variables including tumor location and advanced nodal status influence whether surgery will lead to macro-PSM. Before choosing to proceed with SNSCC surgery, shared decision-making between surgeon and patient should take place on the basis of these findings.
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