Shaheen AA, Kaplan GG, Sharkey KA, et al. - Researchers conducted this population-based study to assess the influence of major depressive disorder (MDD) and antidepressants on survival among patients with alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Between 1986 and 2017, the Health Improvement Network database, the largest medical database in the United Kingdom, was used to identify incident ALD (n = 4,148) and NAFLD (n = 19,053) in patients. The rate of MDD was higher in ALD patients than in NAFLD patients. Antidepressant medication was commonly used in patients with ALD and NAFLD. MDD was not linked to poorer ALD or NAFLD outcomes. Mirtazapine was linked to a higher risk of decompensated cirrhosis or death, which was not seen with other antidepressants. Prospective research is needed to confirm these findings.