Emanuelsson F, et al. - Researchers investigated a causal link between high low-density lipoprotein cholesterol (LDL-C) and the risk of retinopathy, neuropathy, chronic kidney disease (CKD), and peripheral arterial disease (PAD) in the general population. They performed one-sample Mendelian randomization (MR) including 116,419 Danish people. Using summary-level data from the Global Lipid Genetics Consortium (n = 94,595) and the UK Biobank (n = 408,455), they also performed 2-sample MR. Randomized statin trials with 64,134 participants were also analyzed via meta-analysis. Findings revealed the absence of a causal link of high LDL-C with the risk of retinopathy and neuropathy; however, an observational and genetic link of high LDL-C with high risks of PAD and CKD was shown, indicating a causal implication of LDL-C in the pathogenesis of these diseases.