Montes-Cortés DH, et al. - In patients with chronic liver disease (CLD), researchers evaluate if intestinal mannitol is as effective and safe as conventional treatment for diminishing hyperammonemia, oxidative stress, and hepatic encephalopathy. Intestinal mannitol proved to have comparable efficacy and safety profile as conventional treatment for reducing hyperammonemia, oxidative stress, and hepatic encephalopathy of CLD patients in the emergency room. Besides, mannitol is better tolerated than conventional treatment.