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Impact of inflammatory markers on survival in patients with limited disease small-cell lung cancer undergoing chemoradiotherapy

Cancer Management and Research Dec 06, 2018

Bernhardt D, et al. - Researchers evaluated the role of inflammatory markers [Serum C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH), hemoglobin (Hb) levels, and platelet count (Pc)] in limited disease (LD) small-cell lung cancer (SCLC) patients undergoing thoracic chemoradiotherapy (TCR). A total number of 350 SCLC patients diagnosed with LD SCLC who received TCR between 1999 and 2017 and had available blood tests within 2 weeks prior to the start of TCR were retrospectively analyzed. Findings suggest an independent prognostic value of elevated CRP and LDH for OS. However, they identify no independent prognostic value of elevated NLR for OS if taken prior to TCR. LDH and CRP are suggested as valuable for clinical decision making as these are easily available blood tests and require no additional resources.
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