Khurana N, et al. - Researchers sought to assess the effect of improving diagnosis, care, and treatment of persons living with HIV (PLWH) on pre-exposure prophylaxis (PrEP) effectiveness in the United States. Using a dynamic, compartmental model that simulates the sexually active US population, they investigated the change in cumulative HIV incidence from 2016 to 2020 for 3 HIV care-continuum levels and the marginal benefit of PrEP compared with each. Observations revealed larger marginal benefit of PrEP when current HIV-care-continuum percentages were maintained but it continued to be substantial even when national care goals were met. PrEP seemed to benefit the high-risk men who have sex with men population chiefly.