Impact of immune response on outcomes in hepatocellular carcinoma: Association with vascular formation
Hepatology Mar 05, 2020
Itoh S, Yoshizumi T, Yugawa K, et al. - In this large cohort study involving 387 patients, researchers studied the prognostic value of programmed death-ligand 1 (PD-L1) expression, tumor-infiltrating CD8-positive T cell status, and their combination in hepatocellular carcinoma (HCC). Additionally, they explored the connection between PD-L1 expression and vascular formation in the tumor microenvironment. Using a database of patients who had a hepatic resection for HCC, immunohistochemical staining of PD-L1, CD8, and CD34 was conducted. PD-L1-positive HCC patients (n = 76) showed significantly worse overall survival compared with PD-L1-negative HCC patients (n = 311). Findings suggested an association of PD-L1 expression in cancer cells with a poor clinical outcome and vascular formation in HCC patients. Furthermore, combining PD-L1 expression with tumor-infiltrating CD8-positive T cell status allowed patients to be further classified based on their clinical outcome. Therefore, PD-L1 expression in cancer cells and tumor-infiltrating CD8-positive T cell status may serve as biomarkers for the predictive tissue.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries