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Impact of immune response on outcomes in hepatocellular carcinoma: Association with vascular formation

Hepatology Mar 05, 2020

Itoh S, Yoshizumi T, Yugawa K, et al. - In this large cohort study involving 387 patients, researchers studied the prognostic value of programmed death-ligand 1 (PD-L1) expression, tumor-infiltrating CD8-positive T cell status, and their combination in hepatocellular carcinoma (HCC). Additionally, they explored the connection between PD-L1 expression and vascular formation in the tumor microenvironment. Using a database of patients who had a hepatic resection for HCC, immunohistochemical staining of PD-L1, CD8, and CD34 was conducted. PD-L1-positive HCC patients (n = 76) showed significantly worse overall survival compared with PD-L1-negative HCC patients (n = 311). Findings suggested an association of PD-L1 expression in cancer cells with a poor clinical outcome and vascular formation in HCC patients. Furthermore, combining PD-L1 expression with tumor-infiltrating CD8-positive T cell status allowed patients to be further classified based on their clinical outcome. Therefore, PD-L1 expression in cancer cells and tumor-infiltrating CD8-positive T cell status may serve as biomarkers for the predictive tissue.
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