Efstathiou JA, et al. - Investigators examined 136 muscle-invasive bladder cancer (MIBC) patients to assess the prognostic value of immune and stromal signatures in MIBC treated with trimodality therapy (TMT). They identified luminal, luminal-infiltrated, basal, and claudin-low subtypes using gene expression profiling of TMT cases. An association of signatures of T-cell activation and interferon gamma signaling with improved disease-specific survival was observed in the TMT cohort. Higher stromal infiltration was noticed in correlation with shorter DSS after neoadjuvant chemotherapy (NAC) and radical cystectomy (RC).