Chaix I, Manquat E, Liu N, et al. - Given that reductions in mean arterial pressure (MAP) during anesthesia are frequently encountered but the influence on likely cerebral hypoperfusion continues to be a matter of debate, and therefore, researchers assessed cerebral perfusion among patients with or without cardiovascular comorbidities (Hi-risk vs Lo-risk) during induction of general anesthesia and during hypotensive episodes. In a prospective manner, patients scheduled for neuroradiology procedure utilizing standardized target-controlled Propofol-Remifentanil infusion were included. A 10 µg bolus of Norepinephrine was used to treat hypotensive episodes. Transcranial Doppler measuring mean blood velocity of the middle cerebral artery (Vm), Bispectral Index with burst suppression ratio (SR) and cerebral Near-Infrared Spectroscopy were components of monitoring. This study was done with 81 patients, including 37 Hi-risk and 44 Lo-risk. A higher reduction in MAP and Vm, and a higher occurrence of SR during induction of anesthesia was reported in Hi-risk patients vs Lo-risk patients. A rise in Vm consequent to MAP correction with norepinephrine was mainly seen in Hi-rik patients.