Shamekhi J, et al. - Given that high-risk percutaneous coronary interventions (PCI) in patients with complex coronary artery disease might be facilitated by left ventricular (LV) hemodynamic support, researchers compared the outcome between high-risk patients undergoing protected PCI vs those undergoing unprotected high-risk PCI. Of 139 included patients who had non-emergent high-risk PCI, protected PCI was performed on 24 (17%) patients. The occurrence of a major adverse cardiac event (MACE) during the first year was considered the primary endpoint. Although more complex coronary anatomy, a higher comorbidity burden, and more often reduced LV function were observed among patients undergoing protected PCI, there was no difference in 1-year outcome of these patients vs of patients with less complex procedures without hemodynamic support.