Emanuelsson F, et al. - Researchers inquired if there exists a causal genetic effect of high glucose concentrations in the normoglycemic range and higher on the risk of retinopathy, neuropathy, nephropathy, chronic kidney disease, peripheral arterial disease (PAD), and myocardial infarction (MI; positive control) in the general population. This inquiry implemented observational and one-sample Mendelian randomization (MR) analyses to individual-level data from 117,193 Danish people, and confirmation by two-sample MR analyses on summary-level data from 133,010 people from the Meta-Analyses of Glucose and Insulin-Related Traits Consortium, 117,165 from the CKDGen Consortium, and 452,264 from the UK Biobank. Findings revealed a prospective link of glucose levels in the normoglycemic range and higher with a high risk of retinopathy, neuropathy, diabetic nephropathy, estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m², PAD, and MI. These links were corroborated in genetic causal analyses for retinopathy, neuropathy, diabetic nephropathy, and MI, but these could not be validated for PAD and appeared to be denied for eGFR <60 mL/min/1.73 m².