Mauri T, et al. - In this prospective, randomized, cross-over analysis of acute hypoxemic respiratory failure (AHRF) patients [partial oxygen pressure (PaO₂)/inspired oxygen fraction (FiO₂) ≤ 300 + pulmonary infiltrates + exclusion of cardiogenic edema] supported by high-flow nasal cannula (HFNC), researchers investigated if higher temperature and flow decrease patient comfort, presuming higher flow might be associated with improved comfort in more severe patients. They found that for equal flow, lower temperature could be more comfortable. It seemed HFNC temperature had a notable influence on the comfort of AHRF patients. No decrease in patient comfort was reported with the higher flow; at variance, it improved comfort in the more severely hypoxemic patient.